Study of pharmacological and non pharmacological activity of legume polysaccharide
Keywords:
Legume, polysaccharides, pharmacological actions, non-pharmacological actionsAbstract
Legumes, members of the Leguminosae family, including oil seeds like soy and peanuts, and their historical significance in societies worldwide. Only 20 out of approximately 1300 legume species are commonly consumed by humans, with chickpeas, lentils, and soybeans among them. Grain legumes, rich in protein and low in carbohydrates, are vital for nutrition in low-income populations. Processing enhances the nutritional and flavor quality of legumes, affecting starch and dietary fiber content. Despite their importance for human health, animal production, soil improvement, and greenhouse gas mitigation, legumes face challenges compared to major cereals. Genetic improvements and agricultural advancements are essential. The article also touches on polysaccharides, essential biopolymers with diverse biological activities, and highlights the importance of polysaccharides from legumes in various industries, including pharmaceuticals. The research on polysaccharides with anti-diabetic and antioxidant properties is emphasized.
References
Schneider AV. Overview of the market and consumption of puises in Europe. British Journal of Nutrition. 2002 Dec;88(S3):243-50.
Reyes?Moreno C, Paredes?López O, Gonzalez E. Hard?to?cook phenomenon in common beans—A review. Critical Reviews in Food Science & Nutrition. 1993 Jan 1;33(3):227-86.
Reyes-Moreno C, Okamura-Esparza J, Armienta-Rodelo E, Gomez-Garza RM, Milán-Carrillo J. Hard-to-cook phenomenon in chickpeas (Cicerarietinum L): Effect of accelerated storage on quality. Plant Foods for Human Nutrition. 2000 Sep;55(3):229-41.
Tharanathan RN, Mahadevamma S. Grain legumes—a boon to human nutrition. Trends in Food Science & Technology. 2003 Dec 1;14(12):507-18.
Bahadur S, Sahu UK, Sahu D, Sahu G, Roy A. Review on natural gums and mucilage and their application as excipient. Journal of Applied Pharmaceutical Research 5(4), 13-21. (2017)
Gatel F. Protein quality of legume seeds for non-ruminant animals: a literature review. Animal Feed Science and Technology. 1994 Feb 1;45(3-4):317-48.
Biederbeck VO, Zentner RP, Campbell CA. Soil microbial populations and activities as influenced by legume green fallow in a semiarid climate. Soil Biology and Biochemistry. 2005 Oct 1;37(10):1775-84.
Lemke RL, Zhong Z, Campbell CA, Zentner R. Can pulse crops play a role in mitigating greenhouse gases from North American agriculture?. Agronomy Journal. 2007 Nov;99(6):1719-25.
Siddique KH, Johansen C, Turner NC, Jeuffroy MH, Hashem A, Sakar D, Gan Y, Alghamdi SS. Innovations in agronomy for food legumes. A review. Agronomy for sustainable development. 2012 Jan;32(1):45-64.
Dwek RA. Glycobiology: toward understanding the function of sugars. Chemical reviews. 1996 Mar 28;96(2):683-720.
Suárez ER, Syvitski R, Kralovec JA, Noseda MD, Barrow CJ, Ewart HS, Lumsden MD, Grindley TB. Immunostimulatory polysaccharides from Chlorella p yrenoidosa. A new galactofuranan. Measurement of molecular weight and molecular weight dispersion by DOSY NMR. Biomacromolecules. 2006 Aug 14;7(8):2368-76.
Smith F, Montgomery R. Chemistry of plant gums and mucilages and some related polysaccharides.
Wang, D.; Li, C.; Fan, W.; Yi, T.; Wei, A.; Ma, Y. Hypoglycemic and hypolipidemic effects of a polysaccharide from FructusCorni in streptozotocin-induced diabetic rats. Int. J. Biol. Macromol. 2019, 133, 420–427
Lu, A.; Yu, M.; Fang, Z.; Xiao, B.; Guo, L.; Wang, W.; Li, J.; Wang, S.; Zhang, Y. Preparation of the controlled acid hydrolysates from pumpkin polysaccharides and their antioxidant and antidiabetic evaluation. Int. J. Biol. Macromol. 2019, 121, 261–269
Ganesan K, Xu B. Anti-diabetic effects and mechanisms of dietary polysaccharides. Molecules. 2019 Jan;24(14):2556.
Kardošová A, Machová E. Antioxidant activity of medicinal plant polysaccharides. Fitoterapia. 2006 Jul 1;77(5):367-73.
Nayak AK, Pal D. Tamarind seed polysaccharide: an emerging excipient for pharmaceutical use. Indian J Pharm Educ Res. 2017 Apr 1;51:S136-46
Krishnaraj K, Chandrasekar MJ, Nanjan MJ, Muralidharan S, Manikandan D. Development of sustained release antipsychotic tablets using novel polysaccharide isolated from Delonixregia seeds and its pharmacokinetic studies. Saudi Pharmaceutical Journal. 2012 Jul 1;20(3):239-48.
Thambiraj SR, Phillips M, Koyyalamudi SR, Reddy N. Yellow lupin (Lupinus luteus L.) polysaccharides: Antioxidant, immunomodulatory and prebiotic activities and their structural characterisation. Food chemistry. 2018 Nov 30;267:319-28.
Jayamanohar J, Devi PB, Kavitake D, Priyadarisini VB, Shetty PH. Prebiotic potential of water extractable polysaccharide from red kidney bean (Phaseolus vulgaris L.). Lwt. 2019 Mar 1;101:703-10.
Thambiraj SR, Phillips M, Koyyalamudi SR, Reddy N. Antioxidant activities and characterisation of polysaccharides isolated from the seeds of Lupinus angustifolius. Industrial Crops and Products. 2015 Nov 15;74:950-6.
Yao Y, Zhu Y, Ren G. Immunoregulatory activities of polysaccharides from mung bean. Carbohydrate polymers. 2016 Mar 30;139:61-6.
Feregrino-Pe?rez AA, Berumen LC, Garci?a-Alcocer G, Guevara-Gonzalez RG, Ramos-Gomez M, Reynoso-Camacho R, Acosta-Gallegos JA, Loarca-Pin?a G. Composition and chemopreventive effect of polysaccharides from common beans (Phaseolus vulgaris L.) on azoxymethane-induced colon cancer. Journal of agricultural and food chemistry. 2008 Sep 24;56(18):8737-44.
Ktari N, Trabelsi I, Bardaa S, Triki M, Bkhairia I, Salem RB, Nasri M, Salah RB. Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonellafoenum-graecum) seeds. International journal of biological macromolecules. 2017 Feb 1;95:625-34.
Ketha K, Gudipati M. Immunomodulatory activity of non- starch polysaccharides isolated from green gram (Vignaradiata). Food Research International. 2018 Nov 1;113:269-76.
Le B, Pham TN, Yang SH. Prebiotic potential and anti-inflammatory activity of soluble polysaccharides obtained from soybean residue. Foods. 2020 Dec;9(12):1808.
Wu GJ, Liu D, Wan YJ, Huang XJ, Nie SP. Comparison of hypoglycemic effects of polysaccharides from four legume species. Food Hydrocolloids. 2019 May 1;90:299-304.
Bai Z, Meng J, Huang X, Wu G, Zuo S, Nie S. Comparative study on antidiabetic function of six legume crude polysaccharides. International journal of biological macromolecules. 2020 Jul 1;154:25-30.
Kamarudin F, Gan CY. Molecular structure, chemical properties and biological activities of Pinto bean pod polysaccharide. International journal of biological macromolecules. 2016 Jul 1;88:280-7.
Jiang L, Wang W, Wen P, Shen M, Li H, Ren Y, Xiao Y, Song Q, Chen Y, Yu Q, Xie J. Two water-soluble polysaccharides from mung bean skin: Physicochemical characterization, antioxidant and antibacterial activities. Food Hydrocolloids. 2020 Mar 1;100:105412.
He X, Shu J, Xu L, Lu C, Lu A. Inhibitory effect of Astragalus polysaccharides on lipopolysaccharide-induced TNF-a and IL-1? production in THP-1 cells. Molecules. 2012 Mar;17(3):3155-64.
Zhao XN, Liang JL, Chen HB, Liang YE, Guo HZ, Su ZR, Li YC, Zeng HF, Zhang XJ. Anti-fatigue and antioxidant activity of the polysaccharides isolated from Millettiaespeciosae Champ. Leguminosae. Nutrients. 2015 Oct;7(10):8657-69.
Ye Z, Wang W, Yuan Q, Ye H, Sun Y, Zhang H, Zeng X. Box–Behnken design for extraction optimization, characterization and in vitro antioxidant activity of Cicerarietinum L. hull polysaccharides. Carbohydrate polymers. 2016 Aug 20;147:354-64.
Nayak AK, Pal D. Tamarind seed polysaccharide: an emerging excipient for pharmaceutical use. Indian J Pharm Educ Res. 2017 Apr 1;51:S136-46.
Krishnaraj K, Chandrasekar MJ, Nanjan MJ, Muralidharan S, Manikandan D. Development of sustained release antipsychotic tablets using novel polysaccharide isolated from Delonixregia seeds and its pharmacokinetic studies. Saudi Pharmaceutical Journal. 2012 Jul 1;20(3):239-48.
Yadav IK, Jain DA. Design and development of Trigonella foenum graceum seed polysacharide mucilage based matrix tablets of diclofenac sodium. World Journal of Pharmaceutical Research 1 (4), 1170-1182 (2012)
Shukla AK, Kumar M, Bishnoi RS, Jain CP. Application of Fenugreek Seed Gum: In Novel Drug Delivery. Asian journal of biomaterial research. 2017;3(6):1-0.
KSG AK, Palanisamy S, Rajasekaran A. Evaluation of Cassia roxburghii seed gum as binder in tablet formulations of selected drugs. International Journal of Pharmaceutical Sciences and Nanotechnology. 2009;2(4):726-32.
Nadaf S, Jadhav A, Killedar S. Mung bean (Vignaradiata) porous starch for solubility and dissolution enhancement of poorly soluble drug by solid dispersion. International Journal of Biological Macromolecules. 2021 Jan 15;167:345-57.
Prasad YR, Krishnaiah YS, Satyanarayana S. In vitro evaluation of guar gum as a carrier for colon-specific drug delivery. Journal of controlled release. 1998 Feb 12;51(2-3):281-7.
Sravani B, Deveswaran R, Bharath S, Basavaraj BV, Madhavan V. Studies on Vignamungo mucilage as a pharmaceutical excipient. Journal of chemical and pharmaceutical research. 2011;3(2):118-25.
Udeala OK, Uwaga UN. Some emulsifying and suspending properties of a polysaccharide gum derived from Mucunaflagillepes, Papilionaceae. Journal of Pharmacy and Pharmacology. 1981 Sep;33(1):75-8.
Sharma V, Arora V, Ray C. Use of natural superdisintegrant in mouth dissolving tablet-an emerging trend. International bulletin of drug research. 2010;1(2):46-54.
Prajapati VD, Jani GK, Moradiya NG, Randeria NP, Nagar BJ. Locust bean gum: A versatile biopolymer. Carbohydrate polymers. 2013 May 15;94(2):814-21.
Wu G, Bai Z, Wan Y, Shi H, Huang X, Nie S. Antidiabetic effects of polysaccharide from azuki bean (Vignaangularis) in type 2 diabetic rats via insulin/PI3K/AKT signaling pathway. Food Hydrocolloids. 2020 Apr 1;101:105456.
Meng J, Bai Z, Huang W, Liu Y, Wang P, Nie S, Huang X. Polysaccharide from white kidney bean can improve hyperglycemia and hyperlipidemia in diabetic rats. Bioactive Carbohydrates and Dietary Fibre. 2020 Oct 1;24:100222.
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
In submitting an article to Journal of Applied Pharmacognosy and Phytochemistry (JOAPP) I certify that:
- I am authorized by my co-authors to enter into these arrangements.
- I warrant, on behalf of myself and my co-authors, that:
- the article is original, has not been formally published in any other peer-reviewed journal, is not under consideration by any other journal and does not infringe any existing copyright or any other third party rights;
- I am/we are the sole author(s) of the article and have full authority to enter into this agreement and in granting rights to JOAPR are not in breach of any other obligation;
- the article contains nothing that is unlawful, libellous, or which would, if published, constitute a breach of contract or of confidence or of commitment given to secrecy;
- I/we have taken due care to ensure the integrity of the article. To my/our - and currently accepted scientific - knowledge all statements contained in it purporting to be facts are true and any formula or instruction contained in the article will not, if followed accurately, cause any injury, illness or damage to the user.
- I, and all co-authors, agree that the article, if editorially accepted for publication, shall be licensed under the Creative Commons Attribution-NonCommercial 4.0 International License
- I, and all co-authors, agree that, if the article is editorially accepted for publication in Journal of Applied Pharmaceutical Research (JOAPR) data included in the article shall be made available under the Creative Commons 1.0 Public Domain Dedication waiver, unless otherwise stated. For the avoidance of doubt it is stated that sections 1, 2, and 3 of this license agreement shall apply and prevail.



