Exploring plant species for hair fall prevention and hair growth promotion: a comprehensive review

Priyam Jyoti Das; Dhiraj Baishya; Himangshu Deka; Josef Yakin; Nurjamal Hoque; Rosamund Jyrwa

Authors

Priyam Jyoti Das Faculty of Pharmaceutical Science, Assam down town University Panikhaiti, Guwahati-781026, Assam, India
Dhiraj Baishya Assam down town University
Himangshu Deka Faculty of Pharmaceutical Science, Assam down town University Panikhaiti, Guwahati-781026, Assam, India
Josef Yakin Faculty of Pharmaceutical Science, Assam down town University Panikhaiti, Guwahati-781026, Assam, India
Nurjamal Hoque Faculty of Pharmaceutical Science, Assam down town University Panikhaiti, Guwahati-781026, Assam, India
Rosamund Jyrwa Pratiksha Institute of Pharmaceutical Studies Chandrapur road, Panikhaiti, Guwahati-781026, Assam, India

Keywords:

Androgenetic alopecia, Herbal treatment, Plant species, Nutritional Value, Chemical Constituents

Abstract

Background- Mammals' hair has a purpose beyond its physiological function. Culturally, hair is a blank canvas on which one can express oneself and evoke previous and present fads. Today, significant hair loss might be caused by hormonal changes, genetics, a skin problem, or old age. Between 0.2 and 4% of the world's population has this disease, which often worsens physical and mental health. Recent research has focused on herbal hair growth remedies. Natural and alternative medicines are gaining popularity. Methods- Natural therapies, such as plants with therapeutic properties, are being studied to reduce hair loss and grow hair. A comprehensive analysis of plant species researched for hair loss and growth is provided. Result- The review uses traditional knowledge and scientific studies to describe how these plants work, their active components, and their advantages. To determine the efficacy and safety of these plant-based interventions, standardized research protocols, and clinical trials are needed due to differences in study methods, plant preparations, and individual responses. Conclusion- As interest in natural hair care grows, understanding the pros and cons of different plant species is crucial for establishing evidence-based hair fall prevention and growth solutions.

References

Marsh, J., Gray, J., & Tosti, A. Healthy Hair: Form and Function. Healthy Hair, 1–28 (2015).

Lin X, Zhu L, He J. Morphogenesis, growth cycle and molecular regulation of hair follicles. Frontiers in Cell and Developmental Biology, 10, 899095 (2022).

Yu Y, Yang W, Wang B, Meyers MA. Structure and mechanical behavior of human hair. Materials Science and Engineering: C.73:152-63 (2017).

Abu-Naser MHMH and SS. An Expert System for Hair Loss Diagnosis and Treatment Using CLIPS. Int. J. Acad. Eng. Res.5, 37–4 (2021).

Rushton DH, Norris MJ, Dover R, Busuttil N. Causes of hair loss and the developments in hair rejuvenation. Int. J. Cosmet. Sci., 24, 17–23 (2002).

Chumlea WC, Rhodes T, Girman CJ, Johnson-Levonas A, Lilly FRW, Wu R, Guo SS. Family History and Risk of Hair Loss. Dermatology, 209, 33–9 (2004).

Zouboulis CC, Degitz K. Androgen action on human skin – from basic research to clinical significance. Exp. Dermatol., 13, 5–10 (2004).

Reynolds AJ, Oliver RF, Jahoda CA. Dermal cell populations show variable competence in epidermal cell support: stimulatory effects of hair papilla cells. Journal of cell science. 98(1):75-83 (1991).

Whiting DA, Waldstreicher J, Sanchex M, Kaufman KD. Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women. J. Investig. Dermatology Symp. Proc., 4, 282–4 (1999).

Kumar Sumit, Swarankar Vivek, Sharma Sujata BA. Herbal Cosmetics: Used for Skin and Hair. Inven. Rapid. Cosmaceuticals, 1–7 (2012).

Kuber BR, Lavanya C, Haritha CN, Preethi S, Rosa G. Preparation and evaluation of poly herbal hair oil. J. Drug Deliv. Ther., 9, 68–73 (2019).

Bharti M, Shrivastav A, Abid M, Khan NA. A Review on Hair Growth Regulator. J. Drug Deliv. Ther., 10, 368–75 (2020).

Kesika P, Sivamaruthi BS, Thangaleela S, Bharathi M, Chaiyasut C. Role and Mechanisms of Phytochemicals in Hair Growth and Health. Pharmaceuticals, 16(2), 206 (2023).

Jain PK, Das D, Jain P, Jain P. Pharmacognostic and pharmacological aspect of Bacopa monnieri: a review, .Innov J Ayruvedic Sci, 4, 7–11 (2016).

Beck S, Mathison H, Todorov T, Calderon-Juarez E-A, Kopp OR. A Review of Medicinal Uses and Pharmacological Activities of Tridax Procumbens (L.). J. Plant Stud., 7, 19 (2018).

Sahu R, Dhongade HJ, Pandey A, Sahu P, Sahu V, Patel D, Kashyap P. Medicinal Properties of Nardostachys jatamansi (A Review). Orient. J. Chem., 32, 859–66 (2016).

Ru W, Wang D, Xu Y, He X, Sun YE, Qian L, Zhou X, Qin Y. Chemical constituents and bioactivities of Panax ginseng (CA Mey.). Drug discoveries & therapeutics.9(1):23-32 (2015)

Habib-ur-Rehman, Yasin KA, Choudhary MA, Khaliq N, Atta-ur-Rahman, Choudhary MI, Malik S. Studies on the chemical constituents of Phyllanthus emblica. Nat. Prod. Res., 21, 775–81 (2007).

Siddiqui BS, Aslam H, Ali ST, Khan S, Begum S. Chemical constituents of Centella asiatica. J. Asian Nat. Prod. Res., 9, 407–14 (2007).

Sharrif Moghaddasi M SKV. Aloe vera their chemicals composition and applications: A review. Int. J. Biol. Med. Res., 2, 466–71 (2011).

Mahajan N, Rawal S, Verma M, Poddar M, Alok S. A phytopharmacological overview on Ocimum species with special emphasis on Ocimum sanctum. Biomed. Prev. Nutr., 3, 185–92 (2013).

Saini P, Mithal R, Menghani and E. A parasitic Medicinal plant Cuscuta reflexa: An Overview. Int. J. Sci. Eng. Res., 6, 951–9 (2015).

Yadav NK, Arya RK, Dev K, Sharma C, Hossain Z, Meena S, Arya KR, Gayen JR, Datta D, Singh RK. Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects. Oxid. Med. Cell. Longev., 1–18 (2017).

Taylor PTRC. Chemical Constituents from the Flowers of Nyctanthes arbor-tristis. ScienceAsia, 29, 21–30 (2003).

Goyal S, Gupta N, Chatterjee S. Investigating Therapeutic Potential of Trigonella foenum-graecum L. as Our Defense Mechanism against Several Human Diseases. J. Toxicol., 1–10 (2016).

Al-Snafi AE. Chemical constituents, pharmacological effects and therapeutic importance of Hibiscus rosa-sinensis- A review. IOSR J. Pharm., 11, 101–19 (2018).

Maldonado-Celis ME, Yahia EM, Bedoya R, Landázuri P, Loango N, Aguillón J, Restrepo B, Guerrero Ospina JC. Chemical Composition of Mango (Mangifera indica L.) Fruit: Nutritional and Phytochemical Compounds. Front. Plant Sci., 10, 1073 (2019).

Chaudhary SG, Poonia P. Lawsonia inermis Linnaeus: A Phytopharmacological Review. Int. J. Pharm. Sci. Drug Res., 2, 91–8 (2010).

González-Minero FJ, Bravo-Díaz L, Ayala-Gómez A. Rosmarinus officinalis L. (Rosemary): An Ancient Plant with Uses in Personal Healthcare and Cosmetics. Cosmetics, 7, 77 (2020).

Ragasa CY, Austria JPM, Subosa AF, Torres OB, Shen C-C. Chemical Constituents of Amaranthus viridis. Chem. Nat. Compd., 51, 146–7 (2015).

Wei P, Zhao F, Wang Z, Wang Q, Chai X, Hou G, Meng Q. Sesame (Sesamum indicum L.): A Comprehensive Review of Nutritional Value, Phytochemical Composition, Health Benefits, Development of Food, and Industrial Applications. Nutrients, 14, 4079 (2022).

Ogunwande IA, Olawore NO, Adeleke KA, Ekundayo O, Koenig WA. Chemical composition of the leaf volatile oil of Psidium guajava L. growing in Nigeria. Flavour Fragr. J., 18, 136–8 (2003).

Imam Hashmat HA and AA. Neem (Azadirachta indica A. Juss) - A Nature’s Drugstore: An overview. Int. Res. J. Biol. Sci., 1, 76–9 (2012).

Al-Snafi AE. The Pharmaceutical Importance of Althaea officinalis and Althaea rosea?: A Review. Int. J. PharmTech Res., 5, 1378–85 (2013).

Pellizzeri V, Costa R, Grasso E, Dugo G. Valuable products from the flowers of lemon (Citrus limon L. Osbeck) and grapefruit (Citrus paradisi Macfad.) Italian trees. Food Bioprod. Process., 123, 123–33 (2020).

Jeyabalaji V, Kannan GR, Ganeshan P, Raja K, NagarajaGanesh B, Raju P. Extraction and Characterization Studies of Cellulose Derived from the Roots of Acalypha Indica L. J. Nat. Fibers, 19, 4544–56 (2022).

Banerjee S, Anand U, Ghosh S, Ray D, Ray P, Nandy S, Deshmukh GD, Tripathi V, Dey A. Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders. Phyther. Res., 35, 5668–79 (2021).

Bharathi T, Udayakumar R. Phytochemical Screening and Nutrient Content Analysis of Stem and Root of Tridax Procumbens Linn. Int. J. Res, 7, 470–7 (2019).

Disket J, Mann S, Gupta RK. A review on spikenard (Nardostachys jatamansi DC.)-an ‘endangered’essential herb of India. Int. J. Pharm. Chem., 2, 52-60 (2012).

Park S-YL-YLKKPP all 6 authorsSang UPU. Chemical constituents and biological activities of the berry of Panax ginseng. J. Med. Plants Res., 4, 349–53 (2010).

D’souza JJ, D’souza PP, Fazal F, Kumar A, Bhat HP, Baliga MS. Anti-diabetic effects of the Indian indigenous fruit Emblica officinalis Gaertn: active constituents and modes of action. Food Funct., 5, 635 (2014).

He Z, Hu Y, Niu Z, Zhong K, Liu T, Yang M, Ji L, Hu W. A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb. J. Ethnopharmacol., 302, 115865 (2023).

Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules, 25, 1324 (2020).

Singh D, Chaudhuri PK. A review on phytochemical and pharmacological properties of Holy basil (Ocimum sanctum L.). Ind. Crops Prod., 118, 367–82 (2018).

Tanruean K, Poolprasert P, Kumla J, Suwannarach N, Lumyong S. Bioactive compounds content and their biological properties of acetone extract of Cuscuta reflexa Roxb. grown on various host plants. Nat. Prod. Res., 33, 544–7 (2019).

Feng L, Zhai Y-Y, Xu J, Yao W-F, Cao Y-D, Cheng F-F, Bao B-H, Zhang L. A review on traditional uses, phytochemistry and pharmacology of Eclipta prostrata (L.) . J. Ethnopharmacol., 245, 112109 (2019).

Agrawal J, Pal A. Nyctanthes arbor-tristis Linn—A critical ethnopharmacological review. J. Ethnopharmacol., 146, 645–58 (2013).

Yadav UCS, Baquer NZ. Pharmacological effects of Trigonella foenum-graecum L. in health and disease. Pharm. Biol., 52, 243–54 (2014).

Falade OS, Aderogba MA, Kehinde O, Akinpelu BA, Oyedapo BO, Adewusi SR. Studies on the chemical constituents, antioxidants and membrane stability activities of Hibiscus rosa sinensis. Niger J. Nat. Prod. Med., 13, 58-64 (2009).

Rymbai H, Srivastav M, Sharma RR, Patel CR, Singh AK. Bio-active compounds in mango (Mangifera indica L.) and their roles in human health and plant defence–a review. The Journal of Horticultural Science and Biotechnology., 88(4), 369-79 (2013).

Al-Snafi Ae. A Review on Lawsonia Inermis: A Potential Medicinal Plant. Int. J. Curr. Pharm. Res., 1–13 (2019).

Ghasemzadeh Rahbardar M, Hosseinzadeh H. Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. Iran. J. Basic Med. Sci., 23, 1100–12 (2020).

Guria Tanmoy, Mondal Arijit, Singha Tanushree, Singh Jagadish MTK. Pharmacological Actions and Phytoconstituents of Amaranthusspinosus Linn: A Review. Int. J. Pharmacogn. Phytochem. Res., 6, 405–13 (2014).

Hahm T-S, Park S-J, Martin Lo Y. Effects of germination on chemical composition and functional properties of sesame (Sesamum indicum L.) seeds. Bioresour. Technol., 100, 1643–7 (2009).

J. V. Kamath, Nair Rahul, C. K. Ashok Kumar SML. Psidium guajava l: a review. Int. J. Green Pharm., 2(1), (2008).

Eid A, Jaradat N, Elmarzugi N. A Review of chemical constituents and traditional usage of Neem plant (Azadirachta Indica). Palest. Med. Pharm. J., 2, (2017).

Shah SMA, Akhtar N, Akram M, Shah PA, Saeed T, Ahmed K, Asif and HM. Pharmacological activity of Althaea officinalis L. J. Med. Plants Res., 5, 5662–6 (2011).

Moses S Owolabi, Opeyemi N Avoseh, Isiaka A Ogunwande WN, Setzer, Rukayat Ogungbo, Akintayo L Ogundajo OAL and, Flamini G. Chemical composition of Citrus limon (L.) Osbeck growing in southwestern Nigeria: Essential oil chemo types of both peel and leaf of lemon. Am. J. Essent. Oils Nat. Prod., 6, 36–40 (2018).

Bandyopadhyay TSSB. Ethno-Pharmacological Importance and Valuable Phytochemicals of Acalypha indica (L.) A Review. Int. J. Res. Pharm. Sci., 3, 360–8 (2012).