Development and characterization of novel carbopol based hydrogel formulation containing extract of Eclipta prostrata

Authors

  • Monika Bhairam Columbia Institute of Pharmacy, Near Vidhan Sabha, Tekari, Raipur, Chhattisgarh, India 493111
  • Moulik Kumar Columbia Institute of Pharmacy, Near Vidhan Sabha, Tekari, Raipur, Chhattisgarh, India 493111
  • Gunjan Kalyani Columbia Institute of Pharmacy, Near Vidhan Sabha, Tekari, Raipur, Chhattisgarh, India 493111

Keywords:

Hydrogels, Eclipta prostrata, Carbopol-934, Antibacterial, Anticancer

Abstract

The objective of the current work was to create carbomer-based hydrogel formulation that included ethanolic extracts of Eclipta prostrata. Hydrogel play a significant role in encapsulation of various bioactive compounds extract. Eclipta prostrata is a traditional medicinal herb that has been used for a long time in India to treat ailments like hemorrhagic diseases, skin disorders, respiratory problems, coronary heart disease, hair loss, vitiligo, snake bites, and ailments brought on by liver and kidney deficiencies. However, a number of problems, such as a lack of targeting ability and low bioavailability, have restricted the therapeutic efficacy of herbal extracts and components. Networks of hydrophilic polymers called hydrogels may absorb a lot of liquid. They may allow for continuous medication release and are biocompatible. Because of this, investigations on hydrogels in pharmaceutical formulation have become very popular. The prepared herbal hydrogel formulation contains Carbopol-934, Acacia, Glycerin Sodium benzoate & HPMC. This study aims to investigate the effects of different formulation variables on the release of Eclipta prostrata extract from hydrogel with a polymeric composition. The developed herbal hydrogel formulation underwent preliminary testing such as assessments of viscosity, pH, spreadability, rheological investigations, skin irritation tests, homogenous drug content, and accelerated stability stdies. It is possible to draw the conclusion on the basis of evaluation investigation that medicinal herbal hydrogel of Eclipta prostrata may be utilised for the treatment of wounds, antibacterial and antifungal action, anticancer, and anti-inflammatory activity.

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Published

2024-06-11

How to Cite

Bhairam, M., Kumar, M., & Kalyani, G. (2024). Development and characterization of novel carbopol based hydrogel formulation containing extract of Eclipta prostrata. Journal of Applied Pharmacognosy and Phytochemistry, 4(1), 32-37. Retrieved from https://www.joapponline.com/index.php/joapp/article/view/55

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