Development and characterization of novel carbopol based hydrogel formulation containing extract of Eclipta prostrata
Keywords:
Hydrogels, Eclipta prostrata, Carbopol-934, Antibacterial, AnticancerAbstract
The objective of the current work was to create carbomer-based hydrogel formulation that included ethanolic extracts of Eclipta prostrata. Hydrogel play a significant role in encapsulation of various bioactive compounds extract. Eclipta prostrata is a traditional medicinal herb that has been used for a long time in India to treat ailments like hemorrhagic diseases, skin disorders, respiratory problems, coronary heart disease, hair loss, vitiligo, snake bites, and ailments brought on by liver and kidney deficiencies. However, a number of problems, such as a lack of targeting ability and low bioavailability, have restricted the therapeutic efficacy of herbal extracts and components. Networks of hydrophilic polymers called hydrogels may absorb a lot of liquid. They may allow for continuous medication release and are biocompatible. Because of this, investigations on hydrogels in pharmaceutical formulation have become very popular. The prepared herbal hydrogel formulation contains Carbopol-934, Acacia, Glycerin Sodium benzoate & HPMC. This study aims to investigate the effects of different formulation variables on the release of Eclipta prostrata extract from hydrogel with a polymeric composition. The developed herbal hydrogel formulation underwent preliminary testing such as assessments of viscosity, pH, spreadability, rheological investigations, skin irritation tests, homogenous drug content, and accelerated stability stdies. It is possible to draw the conclusion on the basis of evaluation investigation that medicinal herbal hydrogel of Eclipta prostrata may be utilised for the treatment of wounds, antibacterial and antifungal action, anticancer, and anti-inflammatory activity.
References
Lai WF, Rogach AL. Hydrogel-Based Materials for Delivery of Herbal Medicines. ACS Appl Mater Interfaces 9, 11309-20 (2017)
Pandey R, Bhairam M, Shukla SS, Gidwani B. Colloidal and vesicular delivery system for herbal bioactive constituents. Daru 29, 415-38 (2021)
Ali A, Garg P, Goyal R, Kaur G, Li X, Negi P, Valis M, Kuca K, Kulshrestha S. A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing. Plants (Basel) 10, 25 (2020)
Kurre PK, Ghritlahare SK, Jangdey MS. Formulation and Evaluation of Hydro-gel containing Eclipta alba extract. Pharmaceutical and Biosciences Journal 8(5), 27-32 (2020).
Gidwani B, Bhattacharya R, Shukla SS, Pandey RK. Indian spices: past, present and future challenges as the engine for bio-enhancement of drugs: impact of COVID-19. J Sci Food Agric 102, 3065-77 (2022)
Jales STL, Barbosa RdM, de Albuquerque AC, Duarte LHV, da Silva GR, Meirelles LMA, da Silva TMS, Alves AF, Viseras C, Raffin FN, et al. Development and Characterization of Aloe vera Mucilaginous-Based Hydrogels for Psoriasis Treatment. Journal of Composites Science 6(8), 231 (2022)
Chan ES, Yim ZH, Phan SH, Mansa RF, Ravindra P. Encapsulation of herbal aqueous extract through absorption with ca-alginate hydrogel beads. Food and Bioproducts Processing 88(2-3), 195-201 (2010)
Yadav RNS, Agarwala M. Phytochemical analysis of some medicinal plants. Journal of Phytology 12,10-14 (2011)
Gavan A, Colobatiu L, Hanganu D, Bogdan C, Olah NK, Achim M, Mirel S. Development and Evaluation of Hydrogel Wound Dressings Loaded with Herbal Extracts. Processes 10(2), 242 (2022)
Hoque R. Phytochemical analysis and TLC studies of Eclipta alba and Scoparia dulcis plant extract-hot extraction. Int J Drug Dev & Res 11, 12-5 (2019).
Bhairam M, Roy A, Bahadur S, Banafar A, Turkane D. Standardization of herbal medicines–an overview. Journal of Applied Pharmaceutical Research 1, 14-21 (2013).
Ahmed EM. Hydrogel: Preparation, characterization, and applications: A review. Journal of Advanced Research 6, 105-21 (2015).
Aswathy SH, Narendrakumar U, Manjubala I. Commercial hydrogels for biomedical applications. Heliyon 4, 1-13 (2020)
Gul K, Gan RY, Sun CX, Jiao G, Wu DT, Li HB, Kenaan A, Corke H, Fang YP. Recent advances in the structure, synthesis, and applications of natural polymeric hydrogels. Crit Rev Food Sci Nutr 62, 3817-32 (2022)
Fathi M, Ahmadi N, Forouhar A, Hamzeh Atani S. Natural Hydrogels, the Interesting Carriers for Herbal Extracts. Food Reviews International 27, 1-25 (2021)
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