Evaluation of preliminary phytochemical and in vitro antioxidant activity of Homalomena aromatica (Tuber)


  • Madhusmita Kumari Faculty of Pharmaceutical Science, Assam down town University, Panikhaiti, Guwahati-26, Assam
  • Ramen Kalita Faculty of Pharmaceutical Science, Assam down town University, Panikhaiti, Guwahati-26, Assam
  • Biplap Kumar Dey Faculty of Pharmaceutical Science, Assam down town University, Panikhaiti, Guwahati-26, Assam
  • Ananta Choudhury Faculty of Pharmaceutical Science, Assam down town University, Panikhaiti, Guwahati-26, Assam


Homalomena aromatica, tuber, essential oils, therapeutic indication, antioxidant activity


Homalomena aromatica, also called as sugandhimantri which has a local name gansena, it is a small plant with large stem and aromatic in nature which is basically found in the northeast of india. The plant has a mesmerizing aroma that makes widely used in aromatherapy applications. The tuber are known to possess medicinal properties like anti-inflammatory, analgesic, antidepressant, antiseptic, sedative, antispasmodic, treating joint pain, and skin infections.  Not only tuber has medicinal value, but the roots, rhizome, stem also showed numerous pharmacological activity. Homalomena aromatica tuber are rich source of essential oils, which have been attributed for various medicinal uses and one of the major disease is Diabetes mellitus. It was also proved from the review of literature that the tuber of the plant has antioxidant and gives some of the constituent’s presence by the phyto-chemical tests. Thus in this study phytochemical screening and antioxidant activity of Homalomena aromatica (tuber) has been performed and obtained result indicates potent antioxidant activity represented by the plant


Kehie M, Kehie P, Pfoze N L. Phytochemical and ethnopharmacological overview of endangered Homalomena aromatica Schott: An aromatic medicinal herb of Northeast India. Indian Journal of Natural Products and Resources (IJNPR), 8(1), 18-31 (2017)

Policegoudra R S, Goswami S , Aradhya S M , Chatterjee S, Datta S , Sivaswamy R , Chattopadhyay P , Singh L. Bioactive constituents of Homalomena aromatica essential oil and its antifungal activity against dermatophytes and yeasts .Journal de Mycologie Medicale, 22(1),83-87 (2011)

Raomai S, Kumari S, Tandon P. In vitro propagation of Homalomena aromatica Schott An endangered aromatic medicinal herb of Northeast India. Physiol Mol Biol Plants, 19(2), 297-300 (2013)

Auwal M S, Saka S, Mairiga I A, Sanda K A, Shuaibu A, Ibrahim A. Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extracts of Acacia nilotica (Thorn mimosa).Vet Res Forum,5(2), 95–100 (2014)

Ramamurthy V, Sathiyadevi M. Preliminary Phytochemical Screening of Methanol Extract of Indigotera trita Linn. Journal of J Plant Biochemistry & Physiology, 5(2) (2017)

Blois M S. Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199-1200 (1958)

Roy SJ , Baruah PS, Lahkar L, Gurung L, Saikia D , Tanti B. Phytochemical analysis and antioxidant activities of Homalomena aromatica Schott . Journal of Pharmacognosy and Phytochemistry, 8(1), 1379-1385(2019)

Goswami AK, Banu ZW, Sharma HK. CNS effects of Homalomena aromatica based on linalool content: A review. Current trends in pharmaceutical research, 3(2), 20-38(2016)

Alinejad B, Ghorbani A, Sadeghnia HR. Effects of combinations of curcumin, linalool, rutin, safranal and thymoquinone on glucose/serum deprivation induced cell death. Avicenna J Phytomed, 3(4), 321-328 (2016)

Almeida RN, Navarro DS, Barbosa-Filho JM. Plants with central analgesic activity. Phytomedicine, 8(4), 310–322 (2005)

Barua CC, Talukdar A, Phukan B, Hazarika S, Barua AG, Baishya G. Phytochemical screening and in-vitro antioxidant activity of ethanolic extract of Homalomena aromatica (Araceae) root. Der Pharma Lett, 6(1), 128-138 (2014)

Bassil N, Grossberg GT. Novel regimens and delivery systems in the pharmacological treatment of Alzheimer's disease. CNS Drugs, 23(4), 293-307(2009)

Batista PA, Werner MF, Oliveira EC, Burgos L, Pereira P, Brum LF, Santos AR. Evidence for the involvement of ionotropic glutamatergic receptors on the antinociceptive effect of (-)-linalool in mice. Neurosci Lett, 440(3), 299–30 (2008)

Bickers D, Calow P, Greim H, Hanifin JM, Rogers AE, Saurat JH, Sipes IG, Smith RL, Tagami HA. A toxicologic and dermatologic assessment of linalool and related esters when used as fragrance ingredients. Food Chem Toxicol, 41(7), 919–942 (2003)

Buchbauer G, Jirovetz L, Jager W, Dietrich H, Plank C. Aromatherapy:Evidence for sedative effects of the essential oil of lavender after inhalation , Z Naturforsch C, 46,1067–1072 (1991)

Carlini EA. Plants and the central nervous system. Pharmacol Biochem Behav, 75(3), 501–512 (2003)

Celik S, Ozkaya A. Effects of intraperitoneally administered lipoic acid, vitamin E, and linalool on the level of total lipid and fatty acids in guinea pig brain with oxidative stress induced by H2O2. J Biochem Mol Biol, 35(6), 547-552 (2002)

Chadha A, Madyastha KM. Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes. Xenobiotica, 14,365–374 (1984)

Chandana CB, Anindita T, Acheenta GB, Debesh CP, Iswar CB. Ulcer protective activity of ethanolic extract of Homalomena aromatica (Spreng.) Schott. (Araceae) root. Adv Tech Bio Med, 117 (2014)

ChildersSR. Opioid receptor-coupled second messenger systems. Life Sci, 48(21), 1991– 2003 (1991)

Chungsamarnyart N, Jiwajinda S, Jansawan W. Larvicidal effect of plant crude-extracts on the tropical cattle tick (Boophilus microplus). Agric Nat Resoure, 25, 80-89 (1991)

Chungsamarnyart N, Ratanakreetakul C, Jansawan W. Acaricidal activity of the combination of plant crude extracts to tropical cattle ticks. Agric Nat Resoure, 28(4), 649-660 (1994)

Cioanca O, Hritcu L, Mihasan M, Hancianu M. Cognitive-enhancing and antioxidant activities of inhaled coriander volatile oil in amyloid ? (1–42) rat model of Alzheimer's disease. Physiol Behav, 120, 193–202(2013)

De-Almeida ER, Rafael KR, Couto GB, Ishigami AB. Anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and ?-tocopherol present in the extract of leaves of Cissus sicyoides L. (Vitaceae). J Biomed Biotechnol, doi:10.1155/2009/274740 (2009)

Dinda B, Chowdhury DR, Mohanta BC. Naturally occurring iridoids,secoiridoids and their bioactivity: An updated review, part 3. Chem Pharm Bull, 57(8), 765-796 (2009)

Dudhgaonkar SP, Kumar D, Naik A, Devi AR, Bawankule DU, Tandan SK. Interaction of inducible nitric oxide synthase and cyclooxygenase-2 inhibitors in formalin-induced nociception in mice. Eur J Pharmacol, 492(2-3), 117– 122 (2004)

Dutta B, Lahkar M, Augustine BB, Lihite RJ. Hepatoprotective activity of Tamarind indica and Homalomena aromatica in rats. Int J Pharm Pharm Sci, 5(2), 436-438 (2013)

Elisabestky E, Marschner J, Souza DO. Effects of linalool on glutamatergic system in the rat cerebral cortex. Neurochem Res, 20, 461–465 (1995)

Elisabetsky E, Brum LF, Souza DO. Anticonvulsant properties of linalool in glutamate-related seizure models. Phytomedicine, 6(2), 107-113 (1999)

Elisabetsky E, Coelho De Souza GP, Dos Santos MAC, Siqueira IR, Amador TA, Nunes DS. Sedative properties of Linalool. Fitoterapia, 115(5), 407-414 (1995)

García MD, Quílez AM, Sáenz MT, Martínez-Domínguez ME , De-la-puerta R. Anti-inflammatory activity of Agave intermixta Trel. and Cissus sicyoides L.,species used in the Caribbean traditional medicine. J Ethnopharmacol, 71(3), 395–40 (2000)

Gilani AH, Aziz N, Khan MA, Shaheen F, Jabeen Q, Siddiqui BS , Herzig JW. Ethnopharmacological evaluation of the anti-convulsant, sedative and anti-spasmodic activities of Lavandula stoechas L. J Ethnopharmacol, 71 (1-2):161-167.2000

Giorgi O, Orlandi M, Geic M, Corda MG. MK-801 prevents the decrease in 35S-TBPS binding in the rat cerebral cortex induced by pentylenetetrazol kindling. Brain Res Bull, 27(6), 835-837(1991)

Griffiths M, Neal JW, Gasque P. Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins. Int Rev Neurobiol, 82,29–55 (2007)

Hajhashemi V, Ghannadi A, Sharif B. Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. J Ethnopharmacol, 89(1), 67–71(2003)

Hardy M, Kirk-Smith MD, Stretch DD. Replacement of drug treatment for insomnia by ambient odour. Lancet, 346(8976), 701(1995)

Hazarika S, Dhiman S, Rabha B, Bhola RK , Singh L . Repellent activity of some essential oils against Simulium species in India. J Insect Sci, 12, doi:10.1673/031.012.0501 (2012)

Heneka MT, Kummer MP, Latz E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol, 14,463–477 (2014)

Ito Y, Sugimoto A, Kakuda T, Kubota K. Identification of potent odorants in Chinese jasmine green tea scented with flowers of Jasminum sambac . J Agric Food Chem, 50(17), 4878–4884 (2002)

Jager W, Buchbauer G, Jirovetz L, Fritzer M. Percutaneous absorption of lavender oil from a massage oil. J Soc Cosmet Chem, 43, 49–54 (1992)

Kain ZN, Sevarino F, Pincus S, Alexander GM, Wang SM, Ayoub C, Kosarussavadi B . Attenuation of the preoperative stress response with midazolam: effects on postoperative outcomes. Anesthesiology, 93(1), 141-147 (2000)

Kainer KA, Duriea ML. Tapping women's knowledge: Plant resource use in extractive reserves, Acre, Brazil. Econ Bot, 46(4), 408-425(1992)

Kang JH, Ryoo NY, Shin DW, Trojanowski JQ , Shaw LM. Role of cerebrospinal fluid biomarkers in clinical trials for Alzheimer's disease modifying therapies. Korean J Physiol Pharmacol, 18(6), 447-456 (2014)

Katsuse O, Iseki E, Kosaka K. Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with lewy bodies. Neuropathology, 23(1), 9-15 (2003)

Kim KY, Lee HS, Min SS, Seol GH. Neuroprotective effect of (-)-linalool against sodium nitroprusside-induced cytotoxicity. Med Chem, 5, 178-182 (2015)

Komalamisra N, Trongtokit Y, Rongsriyam Y, Apiwathnasorn C. Screening for larvicidal activity in some Thai plants against four mosquito vector species. Southeast Asian J Trop Med Public Health, 36(6), 1412-1422 (2005)

Kuroda K, Inoue N, Ito Y, Kubota K, Sugimoto A, Kakuda T , Fushiki T .Sedative effects of the jasmine tea odor and (R )-(-)-linalool, one of its major odor components, on autonomic nerve activity and mood states. Eur J Appl Physiol, 95(2-3), 107–114 (2005)

Laishram KS, Nath DR, Bailung B, Baruah I. In-viro antibacterial activity of essential oil from rhizome of Homalomena aromatica against pathogenic bacteria. J CellTissue Res, 6(2), 849-851 (2006)

Li Y, Lv O, Zhou F, Li Q, Wu Z, Zheng Y. Linalool Inhibits LPS-induced inflammation in BV2 microglia cells by activating Nrf2. Neurochem Res, 40(7), 15-20 (2015)

Linck VM, DaSilva AL, Figueiro M, Caram EB, Moreno PRH , Elisabetsky E. Effects of inhaled linalool in anxiety, social interaction and aggressive behavior in mice. Phytomedicine, 17(8-9), 679–683 (2010)

Lipton SA, Rosemberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med, 330(90), 613-622 (1994)

Lushchak OV, Lushchak VI. Sodium nitroprusside induces mild oxidative stress in Saccharomyces cerevisiae. Redox Rep, 13(4), 144-152 (2008)

Lyons CR. The role of nitric oxide in inflammation. Adv Immunol, 60, 323– 371 (1995)

Majumdar K, Datta BK. A study on ethnomedicinal usage of plants among the folklore herbalists and Tripuri medical practitioners: Part-II. Nat Prod Radiance, 6(1), 66-73 (2007)

Marcinkiewicz J, Grabowska A, Chain B. Nitric oxide up-regulates the release of inflammatory mediators by mouse macrophages. Eur J Pharmacol, 25(4), 947–951 (1995)




How to Cite

Kumari, M. ., Kalita, R., Dey, B. K. ., & Choudhury, A. . (2021). Evaluation of preliminary phytochemical and in vitro antioxidant activity of Homalomena aromatica (Tuber). Journal of Applied Pharmacognosy and Phytochemistry, 1(1), 15-21. Retrieved from https://www.joapponline.com/index.php/joapp/article/view/9